on German


advisory board

Department of Chemistry & Industrial Chemistry - University of Pisa

The Laboratory of Bioactive Polymeric Materials for Biomedical & Environmental Applications named BIOlab is a branch of the Department of Chemistry & Industrial Chemistry of the University of Pisa located at San Piero a Grado, a suburb of Pisa, 10 km away from the leaning tower square.

Recently, BIOlab has been recognized as a Reference Centre for Biomaterials of the Interuniversity National Consortium for Materials Science & Technology (INSTM) which counts on an association of 44 Italian Universities.

The scientific and technical mission of the Laboratory directed by Prof. Emo Chiellini of the Faculty of Engineering of the University of Pisa, is based on a high interdisciplinary expertise platform enjoying harmonized contributions by scientists with background in Polymer Science & Technology, Organic Chemistry, Industrial Chemistry, Cell & Molecular Biology, Pharmaceutical Technology, Biotechnological Engineering, Chemical Engineering, Computational Chemistry and Environmental Sciences.

Integrated research activities undergoing at BIOlab are focused on the preparation, characterization, processing of new polymeric materials for biomedical, pharmaceutical and environmental applications covering a spectrum of interests in Life and Materials Sciences.

In the area of biomedical field, Tissue Engineering, Regenerative Medicine and Targeted Administration of Non-Conventional Drugs, whereas in the area of environmental applications, ecocompatible packaging for food and non-food applications and plasticulture application as well as metal-free antifouling coatings constitute the topics of major interest requiring a confluence of interdisciplinary expertise as those present in BIOlab.

Biocompatible bioerodible-biodegradable polymeric materials are designed as tailored to the different applications within the modern expectations of nanoscience & nanotechnology.

The Laboratory is holding a consolidate experience in the participation and coordination of EC-funded projects going from the Brite-Euram FP to the 7FP.

List of projects funded by EC:

• SKINTREAT NMP-2007-3.1-2 "Novel Approaches for the Development of Customized Skin Treatments and Services"

• NANOTHER NMP-2007-4.0-4 "Integration of novel NANOparticle based technology for THERapeutics and diagnosis of different types of cancer"

• Marie Curie PIRSES-GA-2008-230791 "HYANJI SCAFFOLD - Hyaluronan-based Injectable Material for Tissue Engineering"

• POLYVER COOP-CT-2006-032967 "Production of Polyhydroxyalkanoates from Olive Oil Mills Wastewater"

• AMBIO NMP4-CT-2005-011827 "Advanced Nanostructured Surfaces for the Control of Biofouling"

• EXPERTISSUES NMP3-CT-2004-500283 "Novel Therapeutic Strategies for Tissue Engineering of Bone and Cartilage using Second Generation Biomimetic Scaffolds"

• STARCHLAYER G1ST-CT-2002-50210 "Production of Easily Recyclable Co-Extruded Sheets Based on the Use of a Renewable, Biodegradable Polymer as an Inner Layer"

• STARCHMOULD G1ST-CT-2002-50173 "Thermal Processing of Biodegradable Starch-Based Nanocomposites"

• PACKTECH G1RT-CT-2002-05068 "Assimilation And Standardisation Of Environmentally Friendly Packaging Technologies Within The Food Industry"

• BIOPAL QLK5-CT-2002-02431 "Algae as raw material for production of bioplastics and biocomposites contributing to sustainable development of European coastal regions"

• NANOPROP G5RD-CT-2002-00834 "Innovative Environmentally Friendly Flame-Retarded Polypropylene Nanocomposites"

• SAMPA HPRN-CT-2002-00202 "Synclinic and Anticlinic Mesophases for Photonic Applications"

• ECOPAC QLK1-CT-2001-01823 "Recyclable and Biodegradable Eco-efficient Packaging Solutions for the Food Industry"

• WHEYPOL G5RD-CT-2001-00591 "Dairy Industry Waste as Source for Sustainable Polymeric Material Production"

• DENTALOPT G5RD-CT-2001-00554 "Low Shrinkage Materials for Dental and Ofthalmic Applications"

• TATLYS G5RD-CT-2000-0294 "A New Biocompatioble Nanoparticle Delivery System For Targeted Release of Fibrinolytic Drugs"

• BIONANOPACK FAIR-CT-98-4416 "Biodegradable Nanocomposites Food Packaging"

• ORCHIS FMRX-CT97-0119 "Optical Research of Chiral Systems"

• Brite EuRam BRE2.CT94.0530 "Bioerodible-Biodegradable Polymeric Materials for Targeted Protein Drug Release"

The BIOlab is consisting of the following facilities:

a)   A Chemical Laboratory for the preparation of polymers and relevant precursors

b)   A Processing Laboratory for conversion of polymers and relative blends and composites to specimen and prototypes for different applications

c)   A Laboratory for Biodegradation tests on plastic items from different sources and validation of packaging designed for food and beverage contact

d)   An Instrumental Section comprising instruments for molecular and bulk properties characterization of polymeric materials including LCA

e)   A Formulation Laboratory for biomedical devices (polymeric nanoparticles, patches, vascular grafts and scaffolds) by phase inversion, electrospinning CAD-Rapid Prototyping

f)   A Cell Culture Laboratory equipped for in-vitro evaluation of biocompatibility and bioactivity of biomedical and pharmaceutical devices. Protocols for cell toxicity & genotoxicity

BIOlab is hosting a Doctorate Course in Biomaterials consociated among the Universities of Bologna, Milan, Pisa (Head Administrative Office) and Siena (www.dcci.unipi.it/biomateriali). This Doctorate together with the Doctorates in Molecular & Experimental Oncology and in Biomolecular Technology has constituted an Interdisciplinary Doctorate School in Biomolecular Sciences of the University of Pisa named BIOS-School.

Instrumentations available at BIOlab:

  Atomic Force Microscope (AFM) (Veeco)

  Liquid Prepolymeric Mixer (Diamac)

  Bioplex System HTF (Biorad)

  Melt Flow Index (Ceast)

  Brookfield Viscometer (DV-II) (Brookfield)

  MODA Biodegradation Apparatus (ISO) - (Hissan Trading)

  Confocal Microscope (Nikon)

  Multichannel Bioreactor at Perfusion & Microgravity (Linari)

  Coulter Counter (Lab Instruments)

  NanoDSC III (CSC/Setaram)

  Differential Scanning Calorimeter (DSC) - (Mettler-Toledo)

  NMR 200MHz (Varian)

  Double Screw Extruder (Collin)

  Pearmilimeter (IF/UNIPI)

  Dynamic Contact Angle (DCAT) - (FKV)

  Pendolum Durometer König Type (TQC)

  Dynamic Mechanical Thermal Analizer (DMTA) - (Rheometrics)

  Photocuring Conveyor (Union Print)

  Electrospinning & CAD-Rapid Prototyping - (Spellman-Linari)

  Rheometer (Rheologica)

  FTIR Spectrometer (Jasco)

  Single Screw Extruder (Gimac)

  Gel Doc Electrophoresis (Biorad)

  Spin Coater (SCS Inc)

  Geletion Timer (Techne)

  Static & Air-forced Incubators (Gribco)

  GLC Apparatus (PerkinElmer)

  Static Contact Angle (SCAT) - (Camte)

  GPC Apparatus (Jasco)

  Thermal Gravimetric Analysis (TGA) - (TA Instrument)

  Hot Stage Optical Microscopy (Mettler-Toledo)

  Thermopress (Collin)

  HPLC Apparatus (Jasco, Waters & PerkinElmer)

  Turbomixer (Valtorta)

  Injection Moulding Press (Sandretto)

  Universal Test Machine (Instron 5200)

  Internal Mixer (Brabender)

  UV Spectrophotometer (Jasco)

  Karl Fischer (Mettler-Toledo)

  UV/VIS-Luminiscent Plate Reader (PerkinElmer)

  Light Single Waffer Spin Processor

  Zeta Potential (Lab Instruments)

Department of Chemistry & Industrial Chemistry
University of Pisa, Pisa (Italy)
Laboratory of Bioactive Polymeric Materials for Biomedical & Environmental Applications (BIOlab)
Head of Laboratory: Prof. Emo Chiellini
Tel: +39 050 2210301 / 2219299
Fax: +39 050 2210332 / 28438
Web: www.dcci.unipi.it

Personnel involved at partial or full time in BIOlab activities - status August 2009: